Selection of Radiolabeled Gastrin Analogs for Peptide Receptor-Targeted Radionuclide Therapy
نویسندگان
چکیده
منابع مشابه
Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy.
UNLABELLED The gastrin/cholecystokinin-2 (CCK-2) receptor has been identified as a possible target for peptide receptor radionuclide imaging and therapy. Several radiolabeled peptides binding to this receptor have been explored in animal models and clinical trials but either low tumor uptake or high renal retention has been found. The aim of this study was to identify a peptide with improved tu...
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A new treatment modality for inoperable or metastasized gastroenteropancreatic tumors is the use of radiolabeled somatostatin analogs. Initial studies with high doses of [(111)In-diethylenetriaminepentaacetic acid (DTPA)(0)]octreotide in patients with metastasized neuroendocrine tumors were encouraging, although partial remissions were uncommon. Another radiolabeled somatostatin analog that is ...
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On their plasma membranes, cells express receptor proteins with high affinity for regulatory peptides, such as somatostatin. Changes in the density of these receptors during disease, for example, overexpression in many tumors, provide the basis for new imaging methods. The first peptide analogues successfully applied for visualization of receptor-positive tumors were radiolabeled somatostatin a...
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ژورنال
عنوان ژورنال: Journal of Nuclear Medicine
سال: 2007
ISSN: 0161-5505
DOI: 10.2967/jnumed.106.037085